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Ng inflammation through the recruitment of macrophages.151,156 This mechanism is confirmed by the IL-1 dependency of IL-1 secretion following inflammasome activation.137 During brain ischemia, activated platelets present in the brain vasculature were shown to release pIL-1 and thereby stimulate endothelial cells to secrete the chemokine CXCL1 and express the endothelial surface adhesion proteins V

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