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Ggers degranulation with release of inflammatory mediators stored in abundant cytoplasmic secretory granules (SGs). This is followed by de novo synthesis and secretion of cytokines/chemokines (2). In contrast to neuronal/neuroendocrine cell exocytosis, where individual SGs fuse at the plasma membrane (PM), MC degranulation involves granule-granule and SG-PM fusion by compound/multigranular exocyto
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