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Cular inflammation (Brecht et al., 2011). 4. Heart. Relaxin acts directly on the heart. The presence of RXFP1 in the heart was first suggested by the demonstration of high-affinity binding sites forHalls et al.relaxin in rat atria (Osheroff et al., 1992; Osheroff and Ho, 1993; Tan et al., 1999). Subsequently, relaxin was shown to be a powerful inotropic and chronotropic agent (Kakouris et al., 199

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