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D the functional importance of these regions has been demonstrated in several cases (16, 17). APell et al.PDB by using VAST (19) yielded many significant hits. Several of the similar structures were members of the PilZ domain, which binds bis-(3 -5 )-cyclic dimeric guanosine monophosphate (c-diGMP) and is involved in bacterial signaling (20). Some other similar structures were members of the pyrid
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